Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation. Proc Natl Acad Sci U S A.
Plé Tam et al. 2022
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun.
Cuesta Bernal et al. 2021
Characterization and Molecular Determinants for β-Lactam Specificity of the Multidrug Efflux Pump AcrD from Salmonella typhimurium. Antibiotics
Ornik-Cha Wilhelm et al. 2021
Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun.
Sumyk et al. 2021
Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants. Front Microbiol.
Tam et al. 2021
Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun.
Alav et al. 2021
Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria. Chem Rev.
Marine et al. 2020
Antimicrobial Sensitivity Assay for Bdellovibrio bacteriovorus. Bio Protoc.
Yousefian et al. 2020
Structural characterization of the EmrAB-TolC efflux complex from E. coli. Biochim Biophys Acta Biomembr.
Marine et al. 2020
A novel method to determine antibiotic sensitivity in Bdellovibrio bacteriovorus reveals a DHFR- dependent natural trimethoprim resistance. Sci Rep.
Foong et al. 2020
Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters. J Antimicrob Chemother.
Tam et al. 2020
Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB. J Mol Biol.
Kobylka Kuth Müller et al. 2020
AcrB: a mean, keen, drug efflux machine. Ann N Y Acad Sci.
Tietgen et al. 2019
Identification of the novel class D β-lactamase OXA-679 involved in carbapenem resistance in Acinetobacter calcoaceticus. J Antimicrob Chemother.
Foong et al. 2019
The chloramphenicol/H+ antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity. J Antimicrob Chemother.
Atzori et al. 2019
Identification and characterization of carbapenem binding sites within the RND- transporter AcrB. Biochim Biophys Acta Biomembr.
Pos KM. 2018
Bacterial efflux transporters in the limelight. Res Microbiol.
Du et al. 2018
Multidrug efflux pumps: structure, function and regulation. Nat Rev Microbiol.
Zomot et al. 2018
A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter. J Mol Biol.
López et al. 2017
Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface. Sci Rep.
Tam et al. 2018
High-Resolution Crystallographic Analysis of AcrB Using Designed Ankyrin Repeat Proteins (DARPins). Methods Mol Biol.
Müller et al. 2017
Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump. J Mol Biol.
Gilardi et al. 2017
Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt. Biochim Biophys Acta Gen Subj.
Masi et al. 2017
Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria. Nat Microbiol.
Schimo et al. 2017
Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex. PLoS One.
Nöll et al. 2017
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc Natl Acad Sci U S A.
Oswald Tam et al. 2016
Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB. Nat Commun.
Vargiu et al. 2016
Editorial: Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria. Front Microbiol.
Sjuts et al. 2016
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc Natl Acad Sci U S A.
Daury et al. 2016
Tripartite assembly of RND multidrug efflux pumps. Nat Commun.
Lytvynenko et al. 2016
Molecular basis of polyspecificity of the Small Multidrug Resistance Efflux Pump AbeS from Acinetobacter baumannii. J Mol Biol.
Hammerschmidt et al. 2016
BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Microbiol.
Du et al. 2015
Structure, mechanism and cooperation of bacterial multidrug transporters. Curr Opin Struct Biol.
Müller et al. 2015
The assembly and disassembly of the AcrAB-TolC three- component multidrug efflux pump. Biol Chem.
Klingler et al. 2015
Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria. J Med Chem.
Ly et al. 2014
A novel packing arrangement of AcrB in the lipid bilayer membrane. FEBS Lett.
Eicher et al. 2014
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Elife.
Cha et al. 2014
Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter. Antimicrob Agents Chemother.
Cha et al. 2014
Cooperative transport mechanism and proton-coupling in the multidrug efflux transporter complex AcrAB-TolC. Membrane Transport Mechanism – 3D structure and beyond. Ed. Krämer, R. and Ziegler, C.
Du et al. 2013
The Machinery and Mechanism of Multidrug Efflux in Gram-negative Bacteria. Microbial Efflux Pumps: Current Research.
Ruggerone et al. 2013
RND efflux pumps: structural information translated into function and inhibition mechanisms. Curr Top Med Chem.
Ong et al. 2013
Detecting substrates bound to the secondary multidrug efflux pump EmrE by DNP-enhanced solid-state NMR. J Am Chem Soc.
Hahn et al. 2013
The outer membrane TolC-like channel HgdD is part of tripartite resistance-nodulation-cell division (RND) efflux systems conferring multiple-drug resistance in the Cyanobacterium Anabaena sp. PCC7120. J Biol Chem.
Eicher et al. 2012
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A.
Reimer et al. 2011
A natural prodrug activation mechanism in nonribosomal peptide synthesis. Nat Chem Biol.
Vargiu et al. 2011
Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations. J Am Chem Soc.
Brandstätter et al. 2011
Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS. Biochim Biophys Acta.
Oswald et al. 2011
Drug resistance: a periplasmic ménage à trois. Chem Biol.
Oberfeld et al. 2011
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2. Am J Physiol Renal Physiol.
Pietras et al. 2010
The use of novel organic gels and hydrogels in protein crystallization. J. Appl. Cryst.
Eicher et al. 2009
Structural and functional aspects of the multidrug efflux pump AcrB. Biol Chem.
Seeger et al. 2009
Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site- directed mutagenesis and carbodiimide labeling. Biochemistry.
Pos KM. 2009
Trinity revealed: Stoichiometric complex assembly of a bacterial multidrug efflux pump. Proc Natl Acad Sci U S A.
Camargo et al. 2009
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology.
Pos KM. 2009
Drug transport mechanism of the AcrB efflux pump. Biochim Biophys Acta.
Bohnert et al. 2008
Site- directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB. J Bacteriol.
Seeger et al. 2008
The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance. Curr Drug Targets.
Gauntlett et al. 2008
Molecular analysis of BcrR, a membrane-bound bacitracin sensor and DNA-binding protein from Enterococcus faecalis. J Biol Chem.
Seeger et al. 2008
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat Struct Mol Biol.
Ramadan et al. 2007
Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger. Pflugers Arch.
Furrer et al. 2007
Functional characterization of a NapA Na(+)/H(+) antiporter from Thermus thermophilus. FEBS Lett.
Seeger et al. 2006
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science.
Ramadan T et al. 2006
Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway. J Cell Physiol.
Saidijam et al. 2006
Microbial drug efflux proteins of the major facilitator superfamily. Curr Drug targets
Dahinden et al. 2005
Identification of a domain in the alpha- subunit of the oxaloacetate decarboxylase Na+ pump that accomplishes complex formation with the gamma-subunit. FEBS J.
Dahinden et al. 2004
Oxaloacetate decarboxylase of Archaeoglobus fulgidus: cloning of genes and expression in Escherichia coli. Arch Microbiol.
Röthlisberger et al. 2004
An antibody library for stabilizing and crystallizing membrane proteins – selecting binders to the citrate carrier CitS. FEBS Lett.
Pos et al. 2004
Crystallographic analysis of AcrB. FEBS Lett.
Saidijam et al. 2003
Collection and characterisation of bacterial membrane proteins. FEBS Lett
Wild et al. 2003
Site-directed sulfhydryl labeling of the oxaloacetate decarboxylase Na+ pump of Klebsiella pneumoniae: helix VIII comprises a portion of the sodium ion channel. Biochemistry
Pos et al. 2002
Purification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein. Acta Crystallogr D Biol Crystallogr.
Schmid et al. 2002
Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase beta subunit in the energy coupling mechanism of the Na+ pump. Eur J Biochem
Kästner et al. 2002
Characterization of the citrate/acetate antiporter CitW of Klebsiella pneumoniae. Arch Microbiol.
Langton et al. 2002
Prokaryote multidrug efflux proteins of the major facilitator superfamily: amplified expression, purification and characterisation. In: Microbial Multidrug Efflux. Eds. Paulsen I. T. and Lewis, K.
Ward et al. 2001
Prokaryote multidrug efflux proteins of the major facilitator superfamily: amplified expression, purification and characterisation. J. Mol. Micro. Biotechnol.
Kästner et al. 2000
The Na+-dependent citrate carrier of Klebsiella pneumoniae: high-level expression and site-directed mutagenesis of asparagine-185 and glutamate-194. Arch Microbiol.
Pos et al. 1998
The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts. J Bacteriol.
Schaffitzel et al. 1998
Identification of an Na+-dependent malonate transporter of Malonomonas rubra and its dependence on two separate genes. J Bacteriol.
Pos et al. 1996
Functional properties of the purified Na(+)-dependent citrate carrier of Klebsiella pneumoniae: evidence for asymmetric orientation of the carrier protein in proteoliposomes. Biochemistry
Pos et al. 1994
Purification of two active fusion proteins of the Na(+)-dependent citrate carrier of Klebsiella pneumoniae. FEBS Lett.
Tan et al. 1992
Localization of peptidases in lactococci. Appl Environ Microbiol.
Tan et al. 1991
Purification and characterization of an endopeptidase from Lactococcus lactis subsp. cremoris Wg2. Appl Environ Microbiol.